NR3A modulates the outer vestibule of the "NMDA" receptor channel.

@article{Wada2006NR3AMT,
  title={NR3A modulates the outer vestibule of the "NMDA" receptor channel.},
  author={Akira Wada and Hiroto Takahashi and Stuart Lipton and H. V. Chen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 51},
  pages={13156-66}
}
Classical NMDA receptors (NMDARs), activated by glycine and glutamate, are heteromultimers comprised of NR1 and NR2 subunits. Coexpression of the novel NR3 family of NMDAR subunits decreases the magnitude of NR1/NR2 receptor-mediated currents or forms glycine-activated channels with the NR1 subunit alone. The second (M2) and third (M3) membrane segments of NR1 and NR2 subunits of classical NMDARs form the core of the channel permeation pathway. Structural information regarding NR1/NR3 channels… CONTINUE READING
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