NR2B-deficient mice are more sensitive to the locomotor stimulant and depressant effects of ethanol.

@article{Badanich2011NR2BdeficientMA,
  title={NR2B-deficient mice are more sensitive to the locomotor stimulant and depressant effects of ethanol.},
  author={Kimberly A. Badanich and Tamara L. Doremus-Fitzwater and Patrick J. Mulholland and Patrick K. Randall and Eric Delpire and Howard C Becker},
  journal={Genes, brain, and behavior},
  year={2011},
  volume={10 7},
  pages={805-816}
}
The NR2B subunit of N-methyl d-aspartate glutamate receptors influences pharmacological properties and confers greater sensitivity to the modulatory effects of ethanol. This study examined behavioral responses to acute ethanol in a conditional knockout mouse model that allowed for a delayed genetic deletion of the NR2B subunit to avoid mouse lethality. Mice lacking the NR2B gene (knockout) were produced by mating NR2B[f/f] mice with CAMKIIa-driven tTA transgenic mice and the tetO-CRE transgenic… CONTINUE READING
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