NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobilization

@article{Bedoui2002NPYME,
  title={NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobilization},
  author={Sammy Bedoui and S. Lechner and T. Gebhardt and H. Nave and S. Hoersten},
  journal={Journal of Neuroimmunology},
  year={2002},
  volume={132},
  pages={25-33}
}
  • Sammy Bedoui, S. Lechner, +2 authors S. Hoersten
  • Published 2002
  • Medicine
  • Journal of Neuroimmunology
  • Sympathetic nervous system (SNS) activation mobilizes blood leukocytes. Under these circumstances, both epinephrine (EPI) and neuropeptide Y (NPY) are released. Therefore, we investigated a possible interaction between these transmitters during leukocyte mobilization, using intravenous catheterization of male adult Lewis rats. Intravenous application of NPY followed by EPI, dose-dependently facilitated, intensified and inhibited EPI-induced leukocytosis with subset-specificity for NK-cells… CONTINUE READING
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    References

    SHOWING 1-10 OF 34 REFERENCES
    Neuropeptide Y (NPY) potentiates phenylephrine-induced mitogen-activated protein kinase activation in primary cardiomyocytes via NPY Y5 receptors.
    • 82
    • PDF
    Neuropeptide Y upregulates the adhesiveness of human endothelial cells for leukocytes.
    • 78
    • PDF
    Neurotransmitters of the sympathetic nerve terminal are powerful chemoattractants for monocytes
    • 135
    Neuropeptide Y potentiates noradrenaline-evoked vasoconstriction: mode of action.
    • 239