NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy

@article{Kalra2004NPYAC,
  title={NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy},
  author={Satya P. Kalra and Pushpa S. Kalra},
  journal={Neuropeptides},
  year={2004},
  volume={38},
  pages={201-211}
}
Subjugation of hypothalamic NPY and cohorts with central leptin gene therapy alleviates dyslipidemia, insulin resistance, and obesity for life-time.
TLDR
Sustained repression of NPY signaling with increased leptin selectively in the hypothalamus can avert environmental obesity and the risks of metabolic diseases.
Hypothalamic regulation of appetite
TLDR
This review highlights the key areas of research in the hypothalamic control of appetite, including the anorexigenic pro-opiomelanocortin/cocaine- and amphetamine-related transcript neurons in the arcuate nucleus of the hypothalamus.
Role of neuropeptides in appetite regulation and obesity – A review
Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome
TLDR
It is reported that stress exaggerates diet-induced obesity through a peripheral mechanism in the abdominal white adipose tissue that is mediated by neuropeptide Y (NPY), and manipulations of NPY2R activity within fat tissue offer new ways to remodel fat and treat obesity and metabolic syndrome.
Assays of Obesity-Regulating Peptide Hormones
TLDR
Food intake and fat deposition are regulated by peptide neurotransmitters, most of them located in the brain, particularly in the hypothalamus, and in the gut, and this includes peptides that are orexigenic and anorectic.
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