NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways.

@article{Vella2011NPYAM,
  title={NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways.},
  author={Kristen R. Vella and Preeti Ramadoss and Francis S Lam and Jamie C Harris and Felix D Ye and Paul D Same and Nicholas F O'Neill and Eleftheria Maratos-Flier and Anthony N. Hollenberg},
  journal={Cell metabolism},
  year={2011},
  volume={14 6},
  pages={780-90}
}
Fasting-induced suppression of the hypothalamic-pituitary-thyroid (HPT) axis is an adaptive response to decrease energy expenditure during food deprivation. Previous studies demonstrate that leptin communicates nutritional status to the HPT axis through thyrotropin-releasing hormone (TRH) in the paraventricular nucleus (PVN) of the hypothalamus. Leptin targets TRH neurons either directly or indirectly via the arcuate nucleus through pro-opiomelanocortin (POMC) and agouti-related peptide… CONTINUE READING
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