NPY Y1 Receptors Differentially Modulate GABAA and NMDA Receptors via Divergent Signal-Transduction Pathways to Reduce Excitability of Amygdala Neurons

@article{Molosh2013NPYYR,
  title={NPY Y1 Receptors Differentially Modulate GABAA and NMDA Receptors via Divergent Signal-Transduction Pathways to Reduce Excitability of Amygdala Neurons},
  author={Andrei I. Molosh and Tammy J. Sajdyk and William A. Truitt and Weiguo Zhu and Gerry Stephen Oxford and Anantha S Shekhar},
  journal={Neuropsychopharmacology},
  year={2013},
  volume={38},
  pages={1352-1364}
}
Neuropeptide Y (NPY) administration into the basolateral amygdala (BLA) decreases anxiety-like behavior, mediated in part through the Y1 receptor (Y1R) isoform. Activation of Y1Rs results in G-protein-mediated reduction of cAMP levels, which results in reduced excitability of amygdala projection neurons. Understanding the mechanisms linking decreased cAMP levels to reduced excitability in amygdala neurons is important for identifying novel anxiolytic targets. We studied the intracellular… CONTINUE READING
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