NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry.

@article{Maginnis2008NPXYMI,
  title={NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry.},
  author={Melissa S. Maginnis and Bernardo A Mainou and Aaron Derdowski and Elizabeth Ann Massopust Johnson and Roy Zent and Terence S Dermody},
  journal={Journal of virology},
  year={2008},
  volume={82 7},
  pages={3181-91}
}
Reovirus cell entry is mediated by attachment to cell surface carbohydrate and junctional adhesion molecule A (JAM-A) and internalization by beta1 integrin. The beta1 integrin cytoplasmic tail contains two NPXY motifs, which function in recruitment of adaptor proteins and clathrin for endocytosis and serve as sorting signals for internalized cargo. As reovirus infection requires disassembly in the endocytic compartment, we investigated the role of the beta1 integrin NPXY motifs in reovirus… CONTINUE READING

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