NPS 1506, a moderate affinity uncompetitive NMDA receptor antagonist: preclinical summary and clinical experience

@article{Mueller2000NPS1A,
  title={NPS 1506, a moderate affinity uncompetitive NMDA receptor antagonist: preclinical summary and clinical experience},
  author={Alan L. Mueller and Linda D. Artman and Manuel F. Balandrin and E Brady and Y Chien and Eric G. Delmar and A. Kierstead and Thomas B. Marriott and Scott T. Moe and Joanna L. Raszkiewicz and Bradford C. Vanwagenen and D. Wells},
  journal={Amino Acids},
  year={2000},
  volume={19},
  pages={177-179}
}
Summary. NPS Pharmaceuticals, Inc. (NPS) has synthesized a series of open-channel blockers with varying potencies at the NMDA receptor. NPS 1506 (Fig. 1) is a moderate affinity antagonist that inhibits NMDA/glycine-induced increases in cytosolic calcium in cultured rat cerebellar granule cells (IC50 = 476 nM) and displaces the binding of [3H]MK-801 to rat cortical membranes (IC50 = 664 nM). 
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