NPR-A-Deficient mice show increased susceptibility to hypoxia-induced pulmonary hypertension.

  title={NPR-A-Deficient mice show increased susceptibility to hypoxia-induced pulmonary hypertension.},
  author={Lan Zhao and L. -K. Long and Nicholas W Morrell and Martin R Wilkins},
  volume={99 5},
BACKGROUND Mice in which the gene encoding NPR-A, a guanylyl cyclase-linked natriuretic peptide receptor, has been disrupted were used to examine the contribution of natriuretic peptides to maintaining pulmonary vascular homeostasis in normal- and low-oxygen environments. METHODS AND RESULTS Wild-type (+/+), heterozygous (+/-), and homozygous null mutants (-/-) were studied. The response of the pulmonary vasculature to atrial, B-type, and C-type natriuretic peptides (ANP, BNP, and CNP) during… CONTINUE READING


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Targeted blocking of gene expression for CGRP receptors elevates pulmonary artery pressure in hypoxic rats.

American journal of physiology. Lung cellular and molecular physiology • 2003
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