NPPC/NPR2 signaling is essential for oocyte meiotic arrest and cumulus oophorus formation during follicular development in the mouse ovary.

@article{Kiyosu2012NPPCNPR2SI,
  title={NPPC/NPR2 signaling is essential for oocyte meiotic arrest and cumulus oophorus formation during follicular development in the mouse ovary.},
  author={Chiyo Kiyosu and Takehito Tsuji and Kaoru Yamada and Shimpei Kajita and Tetsuo Kunieda},
  journal={Reproduction},
  year={2012},
  volume={144 2},
  pages={187-93}
}
Natriuretic peptide type C (NPPC) and its high affinity receptor, natriuretic peptide receptor 2 (NPR2), have been assumed to be involved in female reproduction and have recently been shown to play an essential role in maintaining meiotic arrest of oocytes. However, the overall role of NPPC/NPR2 signaling in female reproduction and ovarian function is still less clear. Here we report the defects observed in oocytes and follicles of mice homozygous for Nppc(lbab) or Npr2(cn), mutant alleles of… CONTINUE READING
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