NPP-type ectophosphodiesterases: unity in diversity.

@article{Stefan2005NPPtypeEU,
  title={NPP-type ectophosphodiesterases: unity in diversity.},
  author={Cristiana Stefan and Silvia Jansen and Mathieu Bollen},
  journal={Trends in biochemical sciences},
  year={2005},
  volume={30 10},
  pages={542-50}
}
Nucleotide pyrophosphatase/phosphodiesterase (NPP)-type ectophosphodiesterases are found at the cell surface as type-I or type-II transmembrane proteins, but are also found extracellularly as secreted or shedded enzymes. They hydrolyze pyrophosphate or phosphodiester bonds in a variety of extracellular compounds including nucleotides, (lyso)phospholipids and choline phosphate esters. Despite their structurally related catalytic domain, each enzyme has well-defined substrate specificity… CONTINUE READING
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