NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells

@article{Zhu2015NPM1AM,
  title={NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells},
  author={Yi Zhu and Minmin Shi and H. Chen and Jiangning Gu and Jiaqiang Zhang and B. Shen and X. Deng and J. Xie and Xi Zhan and Chenghong Peng},
  journal={Oncotarget},
  year={2015},
  volume={6},
  pages={21443 - 21451}
}
  • Yi Zhu, Minmin Shi, +7 authors Chenghong Peng
  • Published 2015
  • Medicine
  • Oncotarget
  • The nucleophosmin (NPM1) activates cancer development and progression in many malignant tumors. However, the regulatory role and underlying mechanisms of NPM1 in pancreatic cancer are unknown. In this study, we showed that NPM1 was up-regulated in PDAC, which indicated a poor prognosis. We also identified NPM1could stimulate aerobic glycolysis and repress fructose-1, 6-bisphosphatase 1 (FBP1) in pancreatic cancer cells. Restoring FBP1 expression partially reversed the tumor-promoting effects of… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 44 CITATIONS, ESTIMATED 46% COVERAGE

    CBX3 promotes proliferation and regulates glycolysis via suppressing FBP1 in pancreatic cancer.

    • L. Chen, Chien-Shan Cheng, +4 authors Zhen Chen
    • Medicine, Biology
    • Biochemical and biophysical research communications
    • 2018

    Targeting FBPase is an emerging novel approach for cancer therapy

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Invalidation of mitophagy by FBP1-mediated repression promotes apoptosis in breast cancer

    • Yifeng Liu, Yulin Jiang, +7 authors Tingmei Chen
    • Medicine, Biology
    • Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
    • 2017

    Fructose-1,6-bisphosphatase is a novel regulator of Wnt/β-Catenin pathway in breast cancer.

    FILTER CITATIONS BY YEAR

    2015
    2020

    CITATION STATISTICS

    • 1 Highly Influenced Citations

    • Averaged 8 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 35 REFERENCES

    Kidney cancer: FBP1 depletion feeds ccRCC

    VIEW 1 EXCERPT

    Absence of nucleophosmin 1 (NPM1) gene mutations in common solid cancers.

    VIEW 1 EXCERPT