NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells

@inproceedings{Zhu2015NPM1AM,
  title={NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells},
  author={Yi Zhu and Minmin Shi and Hao Chen and Jiangning Gu and Jiaqiang Zhang and Baiyong Shen and Xiaxing Deng and Junjie Xie and Xi Zhan and Cheng-Hong Peng},
  booktitle={Oncotarget},
  year={2015}
}
The nucleophosmin (NPM1) activates cancer development and progression in many malignant tumors. However, the regulatory role and underlying mechanisms of NPM1 in pancreatic cancer are unknown. In this study, we showed that NPM1 was up-regulated in PDAC, which indicated a poor prognosis. We also identified NPM1 could stimulate aerobic glycolysis and repress fructose-1, 6-bisphosphatase 1 (FBP1) in pancreatic cancer cells. Restoring FBP1 expression partially reversed the tumor-promoting effects… CONTINUE READING

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