NPM-hMLF1 fusion protein suppresses defects of a Drosophila FTLD model expressing the human FUS gene

@inproceedings{Yamamoto2018NPMhMLF1FP,
  title={NPM-hMLF1 fusion protein suppresses defects of a Drosophila FTLD model expressing the human FUS gene},
  author={Itaru Yamamoto and Yumiko Azuma and Yukie Kushimura and Hideki Yoshida and Ikuko Mizuta and T Mizuno and Morio Ueyama and Yoshitaka Nagai and Takahiko Tokuda and Masamitsu Yamaguchi},
  booktitle={Scientific Reports},
  year={2018}
}
Fused in sarcoma (FUS) was identified as a component of typical inclusions in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). In FTLD, both nuclear and cytoplasmic inclusions with wild-type FUS exist, while cytoplasmic inclusions with a mutant-form of FUS occur in many ALS cases. These observations imply that FUS plays a role across these two diseases. In this study, we examined the effect of several proteins including molecular chaperons on the aberrant eye… CONTINUE READING

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