NPM-ALK inhibits the p53 tumor suppressor pathway in an MDM2 and JNK-dependent manner.

@article{Cui2009NPMALKIT,
  title={NPM-ALK inhibits the p53 tumor suppressor pathway in an MDM2 and JNK-dependent manner.},
  author={Yu-Xin Cui and Alan Kerby and Fiona Kate Elizabeth McDuff and Hongtao Ye and Suzanne D Turner},
  journal={Blood},
  year={2009},
  volume={113 21},
  pages={5217-27}
}
Anaplastic large cell lymphoma (ALCL) is characterized by the presence of the t(2;5)(p23;q35) generating the nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) fusion protein, a hyperactive kinase with transforming properties. Among these properties is the ability to regulate activity of the p53 tumor suppressor protein. In many human cancers, p53 is inactivated by mutation or other means, in some cases as a result of up-regulation of the negative regulator MDM2. However, the majority of ALK… CONTINUE READING
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