NPHS3: new clues for understanding idiopathic nephrotic syndrome

  title={NPHS3: new clues for understanding idiopathic nephrotic syndrome},
  author={Bernward G. Hinkes},
  journal={Pediatric Nephrology},
Hereditary forms of childhood nephrotic syndrome (H-CHNS) have long been counted as rare variants of steroid-resistant nephrotic syndrome (SRNS). This concept must be specified by two new findings: First, a study on nephrotic syndrome manifesting in the first year of life documents that H-CHNS are actually the predominant cause of nephrotic syndrome in infants. Second, the recent identification of autosomal recessive nephrotic syndrome type 3 (NPHS3) caused by mutations in the phospholipase… CONTINUE READING

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