NPC1, intracellular cholesterol trafficking and atherosclerosis.

  title={NPC1, intracellular cholesterol trafficking and atherosclerosis.},
  author={Xiao-hua Yu and Na Jiang and Ping-Bo Yao and Xi-long Zheng and Francisco S Cayabyab and Chao-ke Tang},
  journal={Clinica chimica acta; international journal of clinical chemistry},
Post-lysosomal cholesterol trafficking is an important, but poorly understood process that is essential to maintain lipid homeostasis. Niemann-Pick type C1 (NPC1), an integral membrane protein on the limiting membrane of late endosome/lysosome (LE/LY), is known to accept cholesterol from NPC2 and then mediate cholesterol transport from LE/LY to endoplasmic reticulum (ER) and plasma membrane in a vesicle- or oxysterol-binding protein (OSBP)-related protein 5 (ORP5)-dependent manner. Mutations in… CONTINUE READING
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