• Corpus ID: 43874091

NPC-15199, a novel anti-inflammatory agent, mobilizes intracellular Ca2+ in bladder female transitional carcinoma (BFTC) cells.

@article{Jan2000NPC15199AN,
  title={NPC-15199, a novel anti-inflammatory agent, mobilizes intracellular Ca2+ in bladder female transitional carcinoma (BFTC) cells.},
  author={C-R Jan and C C Yu and J K Huang},
  journal={The Chinese journal of physiology},
  year={2000},
  volume={43 1},
  pages={
          29-33
        }
}
This report demonstrates that NPC-15199 [(N-(9-fluorenylmethoxycarbonyl)L-leucine)], a novel anti-inflammatory agent, increases intracellular Ca2+ concentration ([Ca2+]i) in human bladder female transitional cancer (BFTC) cells. Using fura-2 as a Ca2+ probe, NPC-15199 (0.1-2 mM) was found to increase [Ca2+]i concentration-dependently. The response saturated at 2-5 mM NPC-15199. The [Ca2+]i increase comprised an initial rise, a slow decay, and a plateau. Ca2+ removal partly inhibited the Ca2… 
Effect of NPC-15199 on Ca2+ levels in renal tubular cells.
TLDR
The results suggest that NPC-15199 rapidly increases [Ca2+]i by stimulating both extracellular Ca 2+ influx and intracellular Ca2+ release via as yet unidentified mechanism(s).
Effect of fluoxetine on intracellular Ca2+ levels in bladder female transitional carcinoma (BFTC) cells.
TLDR
Collectively, this study shows that fluoxetine increased [Ca 2+] i in bladder cancer cells in a concentration-dependent fashion, by releasing Ca2+ from thapsigargin-sensitive Ca 2+ stores in an IP3-independent manner, and by inducing Ca2- influx from extracellular medium.
Effect of NPC15199 on [Ca²⁺]i and viability in SCM1 human gastric cancer cells.
TLDR
Together, in SCM1 cells, NPC15199 induced [Ca²⁺]i rises that involved Ca�⁺ entry through PKC-insensitive non-store-operated Ca¬⁺ channels and PLC-independent Ca²⁚ release from the endoplasmic reticulum, and induced Caµ⁺-independent cell death.
Fendiline-Induced Ca2+ movement in A10 smooth muscle cells.
  • Y. Lo, J. Cheng, C. Jan
  • Biology, Computer Science
    The Chinese journal of physiology
  • 2001
TLDR
The findings indicate that in smooth muscle cells fendiline induced [Ca2+]i increases, which acted by activating Ca2+ influx via L-type Ca2+.
Gram‐Positive Antimicrobial Activity of Amino Acid‐Based Hydrogels
TLDR
This co-assembled antimicrobial hydrogel is demonstrated to exhibit selective bactericidal activity for gram-positive bacteria while being biocompatible with normal mammalian cells, showing great potential as an antimicrobial coating for clinical anti-infective applications.
Clomiphene, an ovulation-inducing agent, causes [Ca2+]i increases in human osteoblast-like cells.
TLDR
The results suggest that clomiphene increased [Ca2+]i, in osteoblast-like cells, by releasing intracellular Ca2+ in a phospholipase C-independent manner and by causing nifedipine-sensitive Ca2-sensitive cells.