NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders.

@article{LunaMedina2007NP031112AT,
  title={NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders.},
  author={Rosario Luna-Medina and Marta Cort{\'e}s-Canteli and Susana S{\'a}nchez-Galiano and Jose A Morales-Garc{\'i}a and Ana Beatriz Martinez and Angel Santos and Ana Perez-Castillo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 21},
  pages={5766-76}
}
Inflammation and neurodegeneration coexist in many acute damage and chronic CNS disorders (e.g., stroke, Alzheimer's disease, Parkinson's disease). A well characterized animal model of brain damage involves administration of kainic acid, which causes limbic seizure activity and subsequent neuronal death, especially in the CA1 and CA3 pyramidal cells and interneurons in the hilus of the hippocampus. Our previous work demonstrated a potent anti-inflammatory and neuroprotective effect of two… CONTINUE READING