NOX5 in human spermatozoa: expression, function, and regulation.

  title={NOX5 in human spermatozoa: expression, function, and regulation.},
  author={Boris Musset and Robert A. Clark and Thomas E DeCoursey and G{\'a}bor L. Petheő and Mikl{\'o}s Geiszt and Yumin Chen and John E. Cornell and Carlton A Eddy and Robert G. Brzyski and Amina El Jamali},
  journal={The Journal of biological chemistry},
  volume={287 12},
Physiological and pathological processes in spermatozoa involve the production of reactive oxygen species (ROS), but the identity of the ROS-producing enzyme system(s) remains a matter of speculation. We provide the first evidence that NOX5 NADPH oxidase is expressed and functions in human spermatozoa. Immunofluorescence microscopy detected NOX5 protein in both the flagella/neck region and the acrosome. Functionally, spermatozoa exposed to calcium ionophore, phorbol ester, or H(2)O(2) exhibited… CONTINUE READING


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