NOX2 As a Target for Drug Development: Indications, Possible Complications, and Progress.

@article{Diebold2015NOX2AA,
  title={NOX2 As a Target for Drug Development: Indications, Possible Complications, and Progress.},
  author={Becky A. Diebold and Susan M E Smith and Yang Li and J. David Lambeth},
  journal={Antioxidants & redox signaling},
  year={2015},
  volume={23 5},
  pages={375-405}
}
SIGNIFICANCE NOX2 is important for host defense, and yet is implicated in a large number of diseases in which inflammation plays a role in pathogenesis. These include acute and chronic lung inflammatory diseases, stroke, traumatic brain injury, and neurodegenerative diseases, including Alzheimer's and Parkinson's Diseases. RECENT ADVANCES Recent drug development programs have targeted several NOX isoforms that are implicated in a variety of diseases. The focus has been primarily on NOX4 and… CONTINUE READING