NOX isoforms and reactive oxygen species in vascular health.

  title={NOX isoforms and reactive oxygen species in vascular health.},
  author={Rhian M Touyz and Ana Mar{\'i}a Briones and Mona Sedeek and Dylan Burger and Augosto C Montezano},
  journal={Molecular interventions},
  volume={11 1},
Reactive oxygen species (ROS) are important mediators of cell growth, adhesion, differentiation, migration, senescence, and apoptosis. ROS play an important physiological role in regulating vascular tone and can also contribute to pathological mechanisms related to endothelial dysfunction, vascular reactivity, arterial remodeling, and vascular inflammation. The major source of ROS generated in the cardiovascular system is the NADPH oxidase (NOX) family of enzymes, of which seven members have… CONTINUE READING


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