NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells.

@article{Gupta2007NOVF,
  title={NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells.},
  author={Rajeev Gupta and Dengli Hong and Francisco J. Iborra and Samantha Sarno and Tariq Enver},
  journal={Science},
  year={2007},
  volume={316 5824},
  pages={590-3}
}
Clinically successful hematopoietic cell transplantation is dependent on hematopoietic stem and progenitor cells. Here we identify the matricellular protein Nephroblastoma Overexpressed (Nov, CCN3) as being essential for their functional integrity. Nov expression is restricted to the primitive (CD34) compartments of umbilical vein cord blood, and its knockdown in these cells by lentivirus-mediated RNA interference abrogates their function in vitro and in vivo. Conversely, forced expression of… CONTINUE READING

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