NOTUNG: A Program for Dating Gene Duplications and Optimizing Gene Family Trees

  title={NOTUNG: A Program for Dating Gene Duplications and Optimizing Gene Family Trees},
  author={Kevin C. Chen and Dannie Durand and Martin Farach-Colton},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  volume={7 3-4},
Large scale gene duplication is a major force driving the evolution of genetic functional innovation. Whole genome duplications are widely believed to have played an important role in the evolution of the maize, yeast, and vertebrate genomes. The use of evolutionary trees to analyze the history of gene duplication and estimate duplication times provides a powerful tool for studying this process. Many studies in the molecular evolution literature have used this approach on small data sets, using… CONTINUE READING
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