NOTCHing the bone: insights into multi-functionality.

  title={NOTCHing the bone: insights into multi-functionality.},
  author={Feyza Engin and Brendan Lee},
  volume={46 2},
Evolutionarily conserved Notch signaling plays a critical role during embryonic and postnatal life. The importance of Notch signaling in the determination of cell fate, and the spatio-temporal regulation of proliferation, differentiation and apoptosis has been demonstrated in various different organ systems. However, how Notch signaling affects the bone development was unknown until now. The in vivo effects of Notch signaling in lineage commitment, bone formation and bone resorption were… CONTINUE READING
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