NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells

@inproceedings{Hayashi2015NOTCH2SC,
  title={NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells},
  author={Yoshihiro Hayashi and Makoto Osanai and G Lee},
  booktitle={Oncology reports},
  year={2015}
}
The NOTCH family of membranous receptors plays key roles during development and carcinogenesis. Since NOTCH2, yet not NOTCH1 has been shown essential for murine hepatogenesis, NOTCH2 rather than NOTCH1 may be more relevant to human hepatocarcinogenesis; however, no previous studies have supported this hypothesis. We therefore assessed the role of NOTCH2 in human hepatocellular carcinoma (HCC) by immunohistochemistry and cell culture. Immunohistochemically, 19% of primary HCCs showed nuclear… CONTINUE READING
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