NOTCH1 regulates migration and invasion of skin cancer cells by E-cadherin repression

Abstract

NOTCH1 is a regulator that functions not only in tissue development, but also in cancer pathogenesis. We hypothesized that NOTCH1 is involved in skin cancer cell migration and invasion through regulation of E-cadherin and its transcription factor, Snail. Here, using immunofluorescence and western blots, we show that NOTCH1 is upregulated in skin cancer… (More)
DOI: 10.1007/s11010-011-1125-6

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