NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951

@article{Clappier2010NOTCH1AF,
  title={NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951},
  author={Emmanuelle Clappier and Sandra Collette and Nathalie Grardel and Sandrine Girard and Lissbett Su{\'a}rez and Ghislaine Brunie and Sophie Kaltenbach and Karima Yakouben and Françoise Mazingue and Alain Robert and Patrick Boutard and Dominique Plantaz and P. S. Rohrlich and Pieter Van Vlierberghe and Claude Joseph Preudhomme and J. W. M. Otten and Frank Speleman and Nicole Dastugue and Stefan Suciu and Yves Benoit and Yves Bertrand and H{\'e}l{\`e}ne Cav{\'e}},
  journal={Leukemia},
  year={2010},
  volume={24},
  pages={2023-2031}
}
Risk-adjusted treatment stratification in T-cell acute lymphoblastic leukemias (T-ALLs) is currently based only on early response to chemotherapy. We investigated the prognostic implication of hyperactivation of NOTCH pathway resulting from mutations of NOTCH1 or FBXW7 in children with T-ALL enrolled in EORTC-CLG trials. Overall, 80 out of 134 (60%) patients were NOTCH+ (NOTCH1 and/or FBXW7 mutated). Although clinical presentations were not significantly associated with NOTCH status, NOTCH… CONTINUE READING

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The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-cell acute lymphoblastic leukemia can be separated from NOTCH pathway activation by FBXW7 loss of function

  • C Kox, M Zimmermann, M Stanulla, M Schrappe, WD Ludwig, R Köhler
  • Leukemia 2010 (this issue)
  • 2010

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