NOTCH1 Mutations in Aortic Stenosis: Association with Osteoprotegerin/RANK/RANKL

  title={NOTCH1 Mutations in Aortic Stenosis: Association with Osteoprotegerin/RANK/RANKL},
  author={Olga Irtyuga and Anna Malashicheva and Ekaterina Zhiduleva and Olga Freylikhman and Oxana Rotar and Magnus B{\"a}ck and Svetlana Tarnovskaya and Anna Kostareva and Olga M Moiseeva},
  booktitle={BioMed research international},
Background. The NOTCH pathway is known to be important in the pathogenesis of calcific aortic valve disease, possibly through regulators of osteoprotegerin (OPG), receptor activator of nuclear factor κB (RANK), and its ligand (RANKL) system. The purpose of the present study was to search for possible associations between NOTCH1 gene mutations and circulating levels of OPG and soluble RANKL (sRANKL) in patients with aortic stenosis (AS). Methods. The study was performed on 61 patients with AS… CONTINUE READING