NOTCH1 Aberrations in Chronic Lymphocytic Leukemia

  title={NOTCH1 Aberrations in Chronic Lymphocytic Leukemia},
  author={Emanuela Rosati and Stefano Baldoni and Filomena De Falco and Beatrice Del Papa and Erica Dorillo and Chiara Rompietti and Elisa Albi and Franca Falzetti and Mauro Di Ianni and Paolo Sportoletti},
  booktitle={Front. Oncol.},
Chronic lymphocytic leukemia (CLL) is an incurable B-cell neoplasm characterized by highly variable clinical outcomes. In recent years, genomic and molecular studies revealed a remarkable heterogeneity in CLL, which mirrored the clinical diversity of this disease. These studies profoundly enhanced our understanding of leukemia cell biology and led to the identification of new biomarkers with potential prognostic and therapeutic significance. Accumulating evidence indicates a key role of… CONTINUE READING