NOTCH1–RBPJ complexes drive target gene expression through dynamic interactions with superenhancers

  title={NOTCH1–RBPJ complexes drive target gene expression through dynamic interactions with superenhancers},
  author={Hongfang Wang and Chongzhi Zang and Len Taing and Kelly L Arnett and Yinling Joey Wong and Warren S. Pear and Stephen C. Blacklow and X. Shirley Liu and Jon C. Aster},
  journal={Proceedings of the National Academy of Sciences},
  pages={705 - 710}
Significance Studies focused on understanding how transcription factors control gene expression have shown that transcription-factor binding sites generally greatly exceed the number of regulated genes, making it challenging to identify functional binding sites. Using Notch pathway inhibitors, we identified a subset of Notch-binding sites in leukemia cell genomes that are dynamic, changing in occupancy relatively rapidly when Notch signaling is perturbed. Dynamic Notch sites are highly… 

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SWI/SNF chromatin remodeling controls Notch‐responsive enhancer accessibility

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Varying co-factor requirements for MAML1-dependent transcription at different Notch-responsive target genes

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Chromatin signatures at Notch‐regulated enhancers reveal large‐scale changes in H3K56ac upon activation

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