NOTCH1–RBPJ complexes drive target gene expression through dynamic interactions with superenhancers

@article{Wang2013NOTCH1RBPJCD,
  title={NOTCH1–RBPJ complexes drive target gene expression through dynamic interactions with superenhancers},
  author={Hongfang Wang and C. Zang and Len Taing and K. Arnett and Y. J. Wong and W. Pear and S. Blacklow and X. Liu and J. Aster},
  journal={Proceedings of the National Academy of Sciences},
  year={2013},
  volume={111},
  pages={705 - 710}
}
Significance Studies focused on understanding how transcription factors control gene expression have shown that transcription-factor binding sites generally greatly exceed the number of regulated genes, making it challenging to identify functional binding sites. Using Notch pathway inhibitors, we identified a subset of Notch-binding sites in leukemia cell genomes that are dynamic, changing in occupancy relatively rapidly when Notch signaling is perturbed. Dynamic Notch sites are highly… Expand
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