NOTCH pathway inactivation promotes bladder cancer progression.

  title={NOTCH pathway inactivation promotes bladder cancer progression.},
  author={Antonio Maraver and Pablo J. Fernandez-Marcos and Timothy P. Cash and Marinela M{\'e}ndez-Pertuz and Marta Due{\~n}as and Paolo Maietta and Paola Martinelli and M. {\'A}ngeles Mu{\~n}oz-Mart{\'i}n and M{\'o}nica Mart{\'i}nez-Fern{\'a}ndez and Marta Ca{\~n}amero and Giovanna Roncador and Jorge L. Mart{\'i}nez-Torrecuadrada and Dimitri A. Grivas and Jos{\'e} Luis de la Pompa and Alfonso Valencia and Jes{\'u}s M. Paramio and Francisco X. Real and Manuel Serrano},
  journal={The Journal of clinical investigation},
  volume={125 2},
NOTCH signaling suppresses tumor growth and proliferation in several types of stratified epithelia. Here, we show that missense mutations in NOTCH1 and NOTCH2 found in human bladder cancers result in loss of function. In murine models, genetic ablation of the NOTCH pathway accelerated bladder tumorigenesis and promoted the formation of squamous cell carcinomas, with areas of mesenchymal features. Using bladder cancer cells, we determined that the NOTCH pathway stabilizes the epithelial… 

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