NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS.

@article{Icking2005NOSTRINFA,
  title={NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS.},
  author={Ann Icking and Simone Matt and Nils Opitz and A. A. Wiesenthal and Werner M{\"u}ller-Esterl and Kirstin Schilling},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 21},
  pages={5059-69}
}
Intracellular trafficking of endothelial nitric oxide synthase (eNOS) between different compartments is incompletely understood. Recently, we described a novel eNOS-interacting protein, NOSTRIN, which upon overexpression drives eNOS away from the plasma membrane towards intracellular compartments. Sequence similarity of NOSTRIN and pacsins/syndapins suggested a role for NOSTRIN in endocytosis. Accordingly, we show here that NOSTRIN interacts with the large GTPase dynamin and the actin… CONTINUE READING
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