NOS3 27-bp and IL4 70-bp VNTR Polymorphisms Do Not Contribute to the Risk of Sickle Cell Crisis

A great deal of data support the direct involvement of the vascular endothelium, complex cellular interactions, and global inflammation-mediated cell activation in triggering vasoocclusive crisis (VOC) in sickle cell disease (SCD) [1]. In the transgenic mice model for SCD, it has been shown that nitric oxide (NO) protects the mice from VOC [2]. Elevated… CONTINUE READING