NOS2A and the modulating effect of cigarette smoking in Parkinson's disease.

@article{Hancock2006NOS2AAT,
  title={NOS2A and the modulating effect of cigarette smoking in Parkinson's disease.},
  author={Dana B Hancock and Eden R. Martin and Kenichiro Fujiwara and Mark Stacy and Burton L. Scott and Jeffrey M. Stajich and Rita M Jewett and Yi-Ju Li and Michael A. Hauser and Jeffery M. Vance and William K. Scott},
  journal={Annals of neurology},
  year={2006},
  volume={60 3},
  pages={366-73}
}
OBJECTIVE Inducible nitric oxide synthase, a protein product of NOS2A, generates nitric oxide as a defense mechanism, but excessive levels threaten cellular survival. NOS2A is a candidate gene for Parkinson's disease (PD) that potentially interacts with cigarette smoking. We examined NOS2A for association with PD risk and age at onset (AAO) and for interaction with smoking. METHODS We genotyped 13 NOS2A single nucleotide polymorphisms (SNPs) in 466 singleton families and in a validation set… CONTINUE READING
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