NORs and their transcription competence during the cell cycle.

  title={NORs and their transcription competence during the cell cycle.},
  author={Evgeny Smirnov and Mark{\'e}ta Kalm{\'a}rov{\'a} and Karel Koberna and Zuzana Zemanova and Jan Malinsky and M Ma{\vs}ata and Zuzana Cva{\vc}kov{\'a} and Kyra Michalov{\'a} and Ivan Raska},
  journal={Folia biologica},
  volume={52 3},
In human cells ribosomal genes are organized as clusters, NORs, situated on the short arms of acrocentric chromosomes. It was found that essential components of the RNA polymerase I transcription machinery, including UBF, can be detected on some NORs, termed "competent" NORs, during mitosis. The competent NORs are believed to be transcriptionally active during interphase. However, since individual NORs were not observed in the cell nucleus, their interphase status remains unclear. To address… CONTINUE READING
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