NOR1 is an HSF1- and NRF1-regulated putative tumor suppressor inactivated by promoter hypermethylation in nasopharyngeal carcinoma.

@article{Li2011NOR1IA,
  title={NOR1 is an HSF1- and NRF1-regulated putative tumor suppressor inactivated by promoter hypermethylation in nasopharyngeal carcinoma.},
  author={WenJuan Li and Xiaoling Li and Wei Wang and Xiayu Li and Yixin Tan and M E Guerra Yi and Jian-bo Yang and James B. McCarthy and Wei Xiong and Minghua Wu and Jian Ma and Bo Su and Zuping Zhang and Qianjin Liao and Bo Xiang and Guiyuan Li},
  journal={Carcinogenesis},
  year={2011},
  volume={32 9},
  pages={1305-14}
}
Promoter hypermethylation-mediated silencing of tumor suppressor genes (TSGs) is a hallmark of oncogenesis. Oxidored-nitro domain-containing protein 1 (NOR1) is a candidate TSG that is downregulated in nasopharyngeal carcinoma (NPC). In the present study, we identified a functional NOR1 promoter that is regulated by heat shock factor 1 and nuclear respiratory factor 1. The promoter is located within a CpG island. Hypermethylation of this CpG island was found in NPC tissue samples and cancer… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

A genome - wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci

  • Y. Kobayashi
  • Nat . Genet .
  • 2010

Analysis of gene expression identifies candidate molecular markers in nasopharyngeal carcinoma using microdissection and cDNA microarray

  • Z. Y. Zeng
  • J . Cancer Res . Clin . Oncol .
  • 2007

Similar Papers

Loading similar papers…