NODs in defence: from vulnerable antimicrobial peptides to chronic inflammation.

  title={NODs in defence: from vulnerable antimicrobial peptides to chronic inflammation.},
  author={Laurent Peyrin-Biroulet and C{\'e}cile Vignal and Rodrigue Dessein and Michel Simonet and Pierre Desreumaux and Mathias Chamaillard},
  journal={Trends in microbiology},
  volume={14 10},
Defensins and cathelicidins are prevalent and essential gastrointestinal cationic antimicrobial peptides (CAPs). However, these defensive peptides are not infallible because certain enteropathogens can overcome their protective function. Furthermore, impaired defensin synthesis has been linked to the occurrence of Crohn's disease (CD), a chronic inflammatory bowel disease. Recently, defective bacterial sensing through NOD1 and NOD2 has been related to reduced defensin production, CD… CONTINUE READING

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