NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer.

  title={NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer.},
  author={Aur{\'e}lie Couturier-Maillard and Thomas Secher and Ateequr Rehman and Sylvain Normand and Ad{\`e}le De Arcangelis and Robert H{\"a}sler and Ludovic Huot and Teddy Grandjean and Aude Marchal Bressenot and Anne Delanoye-Crespin and Olivier Gaillot and Stefan Schreiber and Yves Lemoine and Bernhard Ryffel and David Hot and Gabriel N{\'u}{\~n}ez and Grace Chen and Philip Rosenstiel and Mathias Chamaillard},
  journal={The Journal of clinical investigation},
  volume={123 2},
Instability in the composition of gut bacterial communities (dysbiosis) has been linked to common human intestinal disorders, such as Crohn's disease and colorectal cancer. Here, we show that dysbiosis caused by Nod2 deficiency gives rise to a reversible, communicable risk of colitis and colitis-associated carcinogenesis in mice. Loss of either Nod2 or RIP2 resulted in a proinflammatory microenvironment that enhanced epithelial dysplasia following chemically induced injury. The condition could… CONTINUE READING


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