NOD2 is highly expressed in Behçet disease with pulmonary manifestations

  title={NOD2 is highly expressed in Behçet disease with pulmonary manifestations},
  author={Kamel Hamzaoui and Hanadi Abid and Anissa Berraies and Jamel Ammar and Agn{\'e}s Hamzaoui},
  booktitle={Journal of Inflammation},
Excessive Th1 cells and TLRs functions are involved in the pathogenesis of Behcet's disease (BD) in response to bacterial antigens. NOD2, an intracellular pathogen recognition sensor, modulates innate defence to muropeptides derived from various bacterial species. To further define a role for NOD2 in BD, we analysed NOD2 transcriptional responses in BAL-MNC from BD patients with pulmonary manifestations. We analysed NOD1, NOD2, T-bet and TLRs mRNA expression with real-time polymerase chain… CONTINUE READING


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