NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis.

@article{Bruns2012NOD2GV,
  title={NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis.},
  author={Tony Bruns and Jack Peter and Philipp A. Reuken and Dominik H Grabe and Sonja R Schuldes and Julia Brenmoehl and Juergen Schoelmerich and Reiner Wiest and A Stallmach},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2012},
  volume={32 2},
  pages={223-30}
}
BACKGROUND Spontaneous bacterial peritonitis (SBP) is considered as result of bacterial translocation from the gastrointestinal lumen to the mesenteric lymph nodes and subsequent circulation. Variants of the NOD2 gene contribute to bacterial translocation and were associated with SBP in a recent study. METHODS We determined common NOD2 variants by TaqMan polymerase chain reaction and analysed the ascitic fluid neutrophil count and bacterial culture results in 175 prospectively characterized… CONTINUE READING