NOD2 Agonist Promotes the Production of Inflammatory Cytokines in VSMC in Synergy with TLR2 and TLR4 Agonists


OBJECTIVE To investigate the expression of NOD2 in human VSMCs, its role in the production of inflammatory cytokines in VSMC and the possible interaction of NOD2-mediated signaling pathway with those mediated by TLR2 and TLR4. METHODS Human coronary artery smooth muscle cells were stimulated with NOD2 agonist MDP alone or in combination with either TLR2… (More)


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