NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population.

  title={NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population.},
  author={Rupert W L Leong and Alessandro Armuzzi and Tariq Ahmad and May Ling Wong and P Tse and Derek P. Jewell and Joseph J. Y. Sung},
  journal={Alimentary pharmacology & therapeutics},
  volume={17 12},
BACKGROUND Crohn's disease affects people world-wide, but the incidence in Asia is lower than in Western countries. This difference may be due to genetic and/or environmental factors. Three single nucleotide polymorphisms (SNPs) of the NOD2/CARD15 gene have been identified to be independently associated with the development of Crohn's disease in Caucasians. Whether these SNPs are involved in the pathogenesis of Crohn's disease in the Chinese population is unknown. AIM To determine if NOD2… CONTINUE READING
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