NOD1 Activators Link Innate Immunity to Insulin Resistance

  title={NOD1 Activators Link Innate Immunity to Insulin Resistance},
  author={Jonathan D Schertzer and Akhilesh K Tamrakar and Joao Gamelas Magalhaes and Sandra de Souza Pereira and Philip J. Bilan and Morgan D. Fullerton and Zhi Liang Liu and Gregory R Steinberg and Adria Giacca and Dana J Philpott and Amira Klip},
OBJECTIVE Insulin resistance associates with chronic inflammation, and participatory elements of the immune system are emerging. We hypothesized that bacterial elements acting on distinct intracellular pattern recognition receptors of the innate immune system, such as bacterial peptidoglycan (PGN) acting on nucleotide oligomerization domain (NOD) proteins, contribute to insulin resistance. RESEARCH DESIGN AND METHODS Metabolic and inflammatory properties were assessed in wild-type (WT) and… CONTINUE READING
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