NOD proteins: regulators of inflammation in health and disease

@article{Philpott2014NODPR,
  title={NOD proteins: regulators of inflammation in health and disease},
  author={Dana J. Philpott and Matthew T. Sorbara and Susan Jane Robertson and Kenneth Croitoru and Stephen E. Girardin},
  journal={Nature Reviews Immunology},
  year={2014},
  volume={14},
  pages={9-23}
}
Entry of bacteria into host cells is an important virulence mechanism. Through peptidoglycan recognition, the nucleotide-binding oligomerization domain (NOD) proteins NOD1 and NOD2 enable detection of intracellular bacteria and promote their clearance through initiation of a pro-inflammatory transcriptional programme and other host defence pathways, including autophagy. Recent findings have expanded the scope of the cellular compartments monitored by NOD1 and NOD2 and have elucidated the… 

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