NOD macrophages produce high levels of inflammatory cytokines upon encounter of apoptotic or necrotic cells.

@article{Stoffels2004NODMP,
  title={NOD macrophages produce high levels of inflammatory cytokines upon encounter of apoptotic or necrotic cells.},
  author={Katinka Stoffels and Lutgart Overbergh and Annapaula Giulietti and Ahmad Kasran and R Bouillon and Conny A. Gysemans and Chantal Mathieu},
  journal={Journal of autoimmunity},
  year={2004},
  volume={23 1},
  pages={9-15}
}
During the development of type 1 diabetes, pancreatic beta-cells are subject to an immune attack, leading to their apoptotic or necrotic cell death. Apoptotic beta-cells are also present during periods of tissue remodeling, such as in early life. Macrophages should clear apoptotic cells silently without production of pro-inflammatory cytokines. The aim of the present study was to investigate the cytokine pattern of NOD macrophages exposed to apoptotic or necrotic cells in vitro. In contrast to… CONTINUE READING

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