NOD-like receptors and inflammasomes: A review of their canonical and non-canonical signaling pathways.

@article{Platnich2019NODlikeRA,
  title={NOD-like receptors and inflammasomes: A review of their canonical and non-canonical signaling pathways.},
  author={Jaye M. Platnich and Daniel A. Muruve},
  journal={Archives of biochemistry and biophysics},
  year={2019}
}
  • J. Platnich, D. Muruve
  • Published 30 July 2019
  • Biology, Medicine
  • Archives of biochemistry and biophysics
The NOD-like receptor (NLR) family of proteins is a group of pattern recognition receptors (PRRs) known to mediate the initial innate immune response to cellular injury and stress. The NLRP proteins represent a fourteen-member subset of the NLR family that contains an N-terminal pyrin domain. Some NLRs are known to form multi-protein complexes known as inflammasomes. Inflammasomes consist of an NLR, the adaptor protein ASC, and the effector molecule pro-caspase-1. Once activated, these… 
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