NOD-Like Receptors in Infection, Immunity, and Diseases

  title={NOD-Like Receptors in Infection, Immunity, and Diseases},
  author={Young Keun Kim and Jeon-Soo Shin and Moon H. Nahm},
  booktitle={Yonsei medical journal},
Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are pattern-recognition receptors similar to toll-like receptors (TLRs). While TLRs are transmembrane receptors, NLRs are cytoplasmic receptors that play a crucial role in the innate immune response by recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Based on their N-terminal domain, NLRs are divided into four subfamilies: NLRA, NLRB, NLRC, and NLRP. NLRs can… CONTINUE READING
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