NOD-LRR proteins: role in host-microbial interactions and inflammatory disease.

  title={NOD-LRR proteins: role in host-microbial interactions and inflammatory disease.},
  author={Inohara and Chamaillard and Christine McDonald and Gabriel N{\'u}{\~n}ez},
  journal={Annual review of biochemistry},
Nods are cytosolic proteins that contain a nucleotide-binding oligomerization domain (NOD). These proteins include key regulators of apoptosis and pathogen resistance in mammals and plants. A large number of Nods contain leucine-rich repeats (LRRs), hence referred to as NOD-LRR proteins. Genetic variation in several NOD-LRR proteins, including human Nod2, Cryopyrin, and CIITA, as well as mouse Naip5, is associated with inflammatory disease or increased susceptibility to microbial infections… CONTINUE READING
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