Corpus ID: 40547807

NOD / SCID / cnull mouse : an excellent recipient mouse model for engraftment of human cells

@inproceedings{Ito2002NODS,
  title={NOD / SCID / cnull mouse : an excellent recipient mouse model for engraftment of human cells},
  author={Mamoru Ito and Hidefumi Hiramatsu and Kimio Kobayashi and Kazutomo Suzue and Mariko Kawahata and Kyoji Hioki and Yoshito Ueyama and Yoshio Koyanagi and Kazuo Sugamura and Kohichiro Tsuji and Toshio Heike and Tatsutoshi Nakahata},
  year={2002}
}
c null mice and NOD/Shi-scid mice. When human CD34 cells from umbilical cord blood were transplanted into this strain, the engraftment rate in the peripheral circulation, spleen, and bone marrow were significantly higher than that in NOD/Shiscid mice treated with anti-asialo GM1 antibody or in the 2-microglobulin– deficient NOD/LtSz-scid (NOD/SCID/ 2mnull) mice, which were as completely defective in NK cell activity as NOD/SCID/ 

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