NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration

@article{Nicolini2004NODSCIDME,
  title={NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration},
  author={Franck Emmanuel Nicolini and Johanne D. Cashman and Donna Hogge and Richard Keith Humphries and Connie J. Eaves},
  journal={Leukemia},
  year={2004},
  volume={18},
  pages={341-347}
}
Transplantation of immunodeficient mice with human hematopoietic cells has greatly facilitated studies of the earliest stages of human hematopoiesis. These include demonstration of the ability of injected ‘human-specific’ hematopoietic growth factors to enhance the production of human cells at multiple levels of differentiation. In contrast, the effects of continuous exposure to such molecules have not been well investigated. Here, we show that nonobese diabetic severe combined immunodeficiency… CONTINUE READING
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